ctcRbase

Entry Detail

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General Information

Database ID: PRAD07099 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: NIPBL Full Name: NIPBL, cohesin loading factor Category: mRNA Synonyms: CDLS|CDLS1|IDN3|IDN3-B|Scc2 Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 36876759 End Site(bp): 37066413 Gene Summary: This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000164190 HGNC ID: HGNC:28862 Entrez Gene: 25836

Expression Profile of NIPBL Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-124-3p NO YES YES hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-137 YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-192-5p NO YES YES hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-206 YES YES NO hsa-miR-215-5p NO YES YES hsa-miR-21-5p NO YES YES hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES YES YES hsa-miR-217 YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-323a-3p YES NO YES hsa-miR-324-5p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-375 YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-532-3p YES NO YES hsa-miR-543 YES YES NO hsa-miR-590-5p NO YES YES hsa-miR-613 YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-665 YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-96-5p YES YES YES Display: