ctcRbase

Entry Detail

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General Information

Database ID: PRAD07435 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: MAP2K4 Full Name: mitogen-activated protein kinase kinase 4 Category: mRNA Synonyms: JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 12020824 End Site(bp): 12143830 Gene Summary: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] External Links: Ensembl ID: ENSG00000065559 HGNC ID: HGNC:6844 Entrez Gene: 6416

Expression Profile of MAP2K4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-129-2-3p YES NO YES hsa-miR-129-5p YES YES NO hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-137 YES NO YES hsa-miR-141-3p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-199a-5p YES YES NO hsa-miR-199b-5p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-335-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-375 YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-487b-3p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-506-3p YES YES YES hsa-miR-542-3p YES YES NO hsa-miR-582-5p YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-874-3p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: