| ncRNA Symbol: | HFE |
| Full Name: | homeostatic iron regulator |
| Category: | mRNA |
| Synonyms: | HFE1|HH|HLA-H|MVCD7|TFQTL2 |
| Chromosome: | chr6 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 26087281 | End Site(bp): | 26098343 |
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| Gene Summary: | The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
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