ctcRbase

Entry Detail

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General Information

Database ID: PRAD08331 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: KLHL3 Full Name: kelch like family member 3 Category: mRNA Synonyms: PHA2D Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 137617500 End Site(bp): 137736090 Gene Summary: This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012] External Links: Ensembl ID: ENSG00000146021 HGNC ID: HGNC:6354 Entrez Gene: 26249

Expression Profile of KLHL3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-137 YES NO YES hsa-miR-149-5p YES YES YES hsa-miR-153-3p YES NO YES hsa-miR-181c-5p YES YES NO hsa-miR-183-5p YES YES YES hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-223-3p YES YES NO hsa-miR-24-3p YES YES YES hsa-miR-25-3p YES NO YES hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-32-5p YES NO YES hsa-miR-363-3p YES NO YES hsa-miR-367-3p YES NO YES hsa-miR-369-3p YES NO YES hsa-miR-423-5p YES NO YES hsa-miR-429 YES YES YES hsa-miR-448 YES NO YES hsa-miR-454-3p YES YES YES hsa-miR-488-3p YES YES YES hsa-miR-92a-3p YES NO YES hsa-miR-92b-3p YES NO YES Display: