| ncRNA Symbol: | ARAP2 | | Full Name: | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | | Category: | mRNA | | Synonyms: | CENTD1|PARX | | Chromosome: | chr4 | | Strand: | - | | Coordinate: | | Start Site(bp): | 35948221 | End Site(bp): | 36244509 | | | Gene Summary: | The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008] | | External Links: | |
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