ctcRbase

Entry Detail

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General Information

Database ID: SKCM01001 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RNF34 Full Name: ring finger protein 34 Category: mRNA Synonyms: CARP-1|CARP1|RFI|RIF|RIFF|hRFI Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 121400041 End Site(bp): 121430623 Gene Summary: The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012] External Links: Ensembl ID: ENSG00000170633 HGNC ID: HGNC:17297 Entrez Gene: 80196

Expression Profile of RNF34 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-129-2-3p YES NO YES hsa-miR-134-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-205-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-223-3p YES YES YES hsa-miR-300 YES NO YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-34a-5p YES NO YES hsa-miR-34c-5p YES NO YES hsa-miR-381-3p YES NO YES hsa-miR-384 YES YES NO hsa-miR-449a YES NO YES hsa-miR-449b-5p YES NO YES hsa-miR-519d-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-875-5p YES YES NO hsa-miR-93-5p YES YES NO Display: