| ncRNA Symbol: | RNASEH2A |
| Full Name: | ribonuclease H2 subunit A |
| Category: | mRNA |
| Synonyms: | AGS4|JUNB|RNASEHI|RNHIA|RNHL|THSD8 |
| Chromosome: | chr19 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 12802063 | End Site(bp): | 12813638 |
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| Gene Summary: | The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009] |
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