ctcRbase

Entry Detail

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General Information

Database ID: SKCM01481 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: HARS Full Name: histidyl-tRNA synthetase Category: mRNA Synonyms: CMT2W|HRS|USH3B Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 140673173 End Site(bp): 140692024 Gene Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] External Links: Ensembl ID: ENSG00000170445 HGNC ID: HGNC:4816 Entrez Gene: 3035

Expression Profile of HARS Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-191-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-93-5p YES YES NO Display: