ctcRbase

Entry Detail

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General Information

Database ID: SKCM01492 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CTSC Full Name: cathepsin C Category: mRNA Synonyms: CPPI|DPP-I|DPP1|DPPI|HMS|JP|JPD|PALS|PDON1|PLS Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 88293592 End Site(bp): 88337787 Gene Summary: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015] External Links: Ensembl ID: ENSG00000109861 HGNC ID: HGNC:2528 Entrez Gene: 1075

Expression Profile of CTSC Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-137 YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-22-3p YES NO YES hsa-miR-23a-3p YES NO YES hsa-miR-23b-3p YES NO YES hsa-miR-31-5p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-9-5p YES YES NO hsa-miR-98-5p YES NO YES Display: