ctcRbase

Entry Detail

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General Information

Database ID: SKCM01545 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GLS Full Name: glutaminase Category: mRNA Synonyms: AAD20|GAC|GAM|GLS1|KGA Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 190880827 End Site(bp): 190965552 Gene Summary: This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] External Links: Ensembl ID: ENSG00000115419 HGNC ID: HGNC:4331 Entrez Gene: 2744

Expression Profile of GLS Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p NO YES NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-137 YES YES YES hsa-miR-1-3p NO YES YES hsa-miR-141-3p YES YES YES hsa-miR-147a YES NO NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-200a-3p YES YES YES hsa-miR-206 NO YES YES hsa-miR-218-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-301a-3p YES YES NO hsa-miR-302a-3p YES NO YES hsa-miR-302b-3p YES NO YES hsa-miR-302c-3p YES NO YES hsa-miR-302d-3p YES NO YES hsa-miR-302e YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-372-3p YES NO YES hsa-miR-373-3p YES NO YES hsa-miR-377-3p YES YES YES hsa-miR-378a-3p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-422a YES YES NO hsa-miR-448 YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-485-5p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-520a-3p YES NO YES hsa-miR-520b YES NO YES hsa-miR-520c-3p YES NO YES hsa-miR-520d-3p YES NO YES hsa-miR-520e YES NO YES hsa-miR-613 NO YES YES hsa-miR-7-5p YES YES NO hsa-miR-802 YES NO YES Display: