ctcRbase

Entry Detail

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General Information

Database ID: SKCM01741 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TTK Full Name: TTK protein kinase Category: mRNA Synonyms: CT96|ESK|MPH1|MPS1|MPS1L1|PYT Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 80003887 End Site(bp): 80042527 Gene Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] External Links: Ensembl ID: ENSG00000112742 HGNC ID: HGNC:12401 Entrez Gene: 7272

Expression Profile of TTK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-132-3p YES YES YES hsa-miR-140-5p YES YES YES hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-212-3p YES YES YES hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-455-3p YES NO YES hsa-miR-582-5p YES NO YES Display: