ctcRbase

Entry Detail

---



General Information

Database ID: SKCM01756 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DNMT1 Full Name: DNA methyltransferase 1 Category: mRNA Synonyms: ADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|m.HsaI Chromosome: chr19 Strand: - Coordinate: Start Site(bp): 10133345 End Site(bp): 10231286 Gene Summary: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] External Links: Ensembl ID: ENSG00000130816 HGNC ID: HGNC:2976 Entrez Gene: 1786

Expression Profile of DNMT1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-140-5p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-448 YES YES NO Display: