ctcRbase

Entry Detail

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General Information

Database ID: SKCM01816 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DUSP10 Full Name: dual specificity phosphatase 10 Category: mRNA Synonyms: MKP-5|MKP5 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 221701424 End Site(bp): 221742176 Gene Summary: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] External Links: Ensembl ID: ENSG00000143507 HGNC ID: HGNC:3065 Entrez Gene: 11221

Expression Profile of DUSP10 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-137 YES NO YES hsa-miR-17-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-183-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-194-5p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES NO YES hsa-miR-223-3p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-874-3p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES YES NO Display: