ctcRbase

Entry Detail

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General Information

Database ID: SKCM01835 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PRNP Full Name: prion protein Category: mRNA Synonyms: ASCR|AltPrP|CD230|CJD|GSS|KURU|PRIP|PrP|PrP27-30|PrP33-35C|PrPc|p27-30 Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 4686236 End Site(bp): 4701590 Gene Summary: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] External Links: Ensembl ID: ENSG00000171867 HGNC ID: HGNC:9449 Entrez Gene: 5621

Expression Profile of PRNP Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES YES hsa-miR-324-5p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO hsa-miR-93-5p YES YES NO Display: