ctcRbase

Entry Detail

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General Information

Database ID: SKCM01904 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SPOP Full Name: speckle type BTB/POZ protein Category: mRNA Synonyms: BTBD32|TEF2 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 49598884 End Site(bp): 49678234 Gene Summary: This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000121067 HGNC ID: HGNC:11254 Entrez Gene: 8405

Expression Profile of SPOP Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES YES YES hsa-miR-149-5p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-342-3p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-375 YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-543 YES YES NO hsa-miR-579-3p YES NO NO hsa-miR-599 YES YES NO Display: