ctcRbase

Entry Detail

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General Information

Database ID: SKCM01913 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ACLY Full Name: ATP citrate lyase Category: mRNA Synonyms: ACL|ATPCL|CLATP Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 41866908 End Site(bp): 41930542 Gene Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014] External Links: Ensembl ID: ENSG00000131473 HGNC ID: HGNC:115 Entrez Gene: 47

Expression Profile of ACLY Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-22-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-758-3p YES YES NO Display: