ctcRbase

Entry Detail

---



General Information

Database ID: SKCM01914 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CDC6 Full Name: cell division cycle 6 Category: mRNA Synonyms: CDC18L|HsCDC18|HsCDC6|MGORS5 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 40287633 End Site(bp): 40304657 Gene Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000094804 HGNC ID: HGNC:1744 Entrez Gene: 990

Expression Profile of CDC6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-199a-5p YES YES NO hsa-miR-199b-5p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES YES NO Display: