| ncRNA Symbol: | DCPS | | Full Name: | decapping enzyme, scavenger | | Category: | mRNA | | Synonyms: | ARS|DCS1|HINT-5|HINT5|HSL1|HSPC015 | | Chromosome: | chr11 | | Strand: | + | | Coordinate: | | Start Site(bp): | 126303752 | End Site(bp): | 126345749 |
| | Gene Summary: | This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017] | | External Links: | |
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