ctcRbase

Entry Detail

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General Information

Database ID: SKCM02071 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: NUDT15 Full Name: nudix hydrolase 15 Category: mRNA Synonyms: MTH2|NUDT15D Chromosome: chr13 Strand: + Coordinate: Start Site(bp): 48037567 End Site(bp): 48047222 Gene Summary: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016] External Links: Ensembl ID: ENSG00000136159 HGNC ID: HGNC:23063 Entrez Gene: 55270

Expression Profile of NUDT15 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-98-5p YES YES NO Display: