ctcRbase

Entry Detail

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General Information

Database ID: SKCM02250 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SORD Full Name: sorbitol dehydrogenase Category: mRNA Synonyms: HEL-S-95n|SORD1 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 45023104 End Site(bp): 45077185 Gene Summary: Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010] External Links: Ensembl ID: ENSG00000140263 HGNC ID: HGNC:11184 Entrez Gene: 6652

Expression Profile of SORD Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-125a-5p YES YES NO hsa-miR-125b-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-874-3p YES YES NO Display: