ctcRbase

Entry Detail

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General Information

Database ID: SKCM02280 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: IMPA1 Full Name: inositol monophosphatase 1 Category: mRNA Synonyms: IMP|IMPA|MRT59 Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 81657961 End Site(bp): 81686693 Gene Summary: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014] External Links: Ensembl ID: ENSG00000133731 HGNC ID: HGNC:6050 Entrez Gene: 3612

Expression Profile of IMPA1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-103a-3p NO YES YES hsa-miR-107 NO YES YES hsa-miR-141-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-365a-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-429 YES YES NO hsa-miR-433-3p YES YES YES hsa-miR-495-3p YES YES NO Display: