ctcRbase

Entry Detail

---



General Information

Database ID: SKCM02282 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ATM Full Name: ATM serine/threonine kinase Category: mRNA Synonyms: AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 108222484 End Site(bp): 108369102 Gene Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] External Links: Ensembl ID: ENSG00000149311 HGNC ID: HGNC:795 Entrez Gene: 472

Expression Profile of ATM Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-543 YES YES NO Display: