ctcRbase

Entry Detail

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General Information

Database ID: SKCM02289 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GLUD1 Full Name: glutamate dehydrogenase 1 Category: mRNA Synonyms: GDH|GDH1|GLUD Chromosome: chr10 Strand: - Coordinate: Start Site(bp): 87050486 End Site(bp): 87094866 Gene Summary: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016] External Links: Ensembl ID: ENSG00000148672 HGNC ID: HGNC:4335 Entrez Gene: 2746

Expression Profile of GLUD1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-124-3p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-182-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-876-5p YES YES NO Display: