ctcRbase

Entry Detail

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General Information

Database ID: SKCM02294 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: FBXO22 Full Name: F-box protein 22 Category: mRNA Synonyms: FBX22|FISTC1 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 75903859 End Site(bp): 75942510 Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] External Links: Ensembl ID: ENSG00000167196 HGNC ID: HGNC:13593 Entrez Gene: 26263

Expression Profile of FBXO22 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-206 YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-613 YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-98-5p YES YES NO Display: