ctcRbase

Entry Detail

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General Information

Database ID: SKCM02301 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ITGA6 Full Name: integrin subunit alpha 6 Category: mRNA Synonyms: CD49f|ITGA6B|VLA-6 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 172427354 End Site(bp): 172506282 Gene Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] External Links: Ensembl ID: ENSG00000091409 HGNC ID: HGNC:6142 Entrez Gene: 3655

Expression Profile of ITGA6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-126-3p YES NO YES hsa-miR-127-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-1297 YES NO YES hsa-miR-134-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-143-3p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-154-5p YES YES NO hsa-miR-186-5p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-299-3p YES YES NO hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-300 YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-377-3p YES YES YES hsa-miR-381-3p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-485-5p YES YES NO hsa-miR-487b-3p YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES NO NO hsa-miR-653-5p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-9-5p YES NO YES Display: