ctcRbase

Entry Detail

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General Information

Database ID: SKCM02322 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DUSP3 Full Name: dual specificity phosphatase 3 Category: mRNA Synonyms: VHR Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 43766121 End Site(bp): 43778988 Gene Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000108861 HGNC ID: HGNC:3069 Entrez Gene: 1845

Expression Profile of DUSP3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-129-5p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-191-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-346 YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-370-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-384 YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-758-3p YES YES NO Display: