ctcRbase

Entry Detail

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General Information

Database ID: SKCM02341 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: EXOSC6 Full Name: exosome component 6 Category: mRNA Synonyms: EAP4|MTR3|Mtr3p|hMtr3p|p11 Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 70246778 End Site(bp): 70251930 Gene Summary: This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000223496 HGNC ID: HGNC:19055 Entrez Gene: 118460

Expression Profile of EXOSC6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-485-5p YES YES NO Display: