ctcRbase

Entry Detail

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General Information

Database ID: SKCM02437 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GCSH Full Name: glycine cleavage system protein H Category: mRNA Synonyms: GCE|NKH Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 81081938 End Site(bp): 81096425 Gene Summary: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.[provided by RefSeq, Jan 2010] External Links: Ensembl ID: ENSG00000140905 HGNC ID: HGNC:4208 Entrez Gene: 2653

Expression Profile of GCSH Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-208a-3p YES YES YES hsa-miR-208b-3p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-499a-5p YES YES YES Display: