ctcRbase

Entry Detail

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General Information

Database ID: SKCM02470 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TXNRD1 Full Name: thioredoxin reductase 1 Category: mRNA Synonyms: GRIM-12|TR|TR1|TRXR1|TXNR Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 104215779 End Site(bp): 104350305 Gene Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017] External Links: Ensembl ID: ENSG00000198431 HGNC ID: HGNC:12437 Entrez Gene: 7296

Expression Profile of TXNRD1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-132-3p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-204-5p YES YES NO hsa-miR-205-5p YES YES YES hsa-miR-211-5p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-324-5p YES YES NO hsa-miR-346 YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-421 YES YES YES hsa-miR-491-5p YES YES NO hsa-miR-495-3p YES NO YES hsa-miR-506-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-874-3p YES YES NO hsa-miR-875-5p YES YES NO Display: