ctcRbase

Entry Detail

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General Information

Database ID: SKCM02509 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PRKAR2A Full Name: protein kinase cAMP-dependent type II regulatory subunit alpha Category: mRNA Synonyms: PKR2|PRKAR2 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 48744597 End Site(bp): 48847846 Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000114302 HGNC ID: HGNC:9391 Entrez Gene: 5576

Expression Profile of PRKAR2A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-139-5p YES YES YES hsa-miR-140-5p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-185-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-218-5p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-365a-3p YES YES YES hsa-miR-424-5p YES YES YES hsa-miR-497-5p YES YES YES hsa-miR-873-5p YES YES YES hsa-miR-9-5p YES YES NO Display: