ctcRbase

Entry Detail

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General Information

Database ID: SKCM02618 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: NEIL2 Full Name: nei like DNA glycosylase 2 Category: mRNA Synonyms: NEH2|NEI2 Chromosome: chr8 Strand: + Coordinate: Start Site(bp): 11769639 End Site(bp): 11787346 Gene Summary: This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017] External Links: Ensembl ID: ENSG00000154328 HGNC ID: HGNC:18956 Entrez Gene: 252969

Expression Profile of NEIL2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-132-3p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-708-5p YES YES NO Display: