ctcRbase

Entry Detail

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General Information

Database ID: SKCM02644 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DUSP6 Full Name: dual specificity phosphatase 6 Category: mRNA Synonyms: HH19|MKP3|PYST1 Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 89347232 End Site(bp): 89353271 Gene Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014] External Links: Ensembl ID: ENSG00000139318 HGNC ID: HGNC:3072 Entrez Gene: 1848

Expression Profile of DUSP6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-137 YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-204-5p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-211-5p YES YES YES hsa-miR-216b-5p YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-342-3p YES YES YES hsa-miR-361-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-377-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-450a-5p YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-496 YES YES NO hsa-miR-506-3p YES YES YES hsa-miR-519d-3p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES YES NO hsa-miR-9-5p YES YES YES hsa-miR-98-5p YES YES NO Display: