ctcRbase

Entry Detail

---



General Information

Database ID: SKCM02645 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CKAP5 Full Name: cytoskeleton associated protein 5 Category: mRNA Synonyms: CHTOG|MSPS|TOG|TOGp|ch-TOG Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 46743048 End Site(bp): 46846308 Gene Summary: This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] External Links: Ensembl ID: ENSG00000175216 HGNC ID: HGNC:28959 Entrez Gene: 9793

Expression Profile of CKAP5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1197 YES NO YES hsa-miR-1224-5p YES NO YES hsa-miR-155-5p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-340-5p YES YES YES hsa-miR-370-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-497-5p YES YES NO Display: