ctcRbase

Entry Detail

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General Information

Database ID: SKCM02656 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MRPL10 Full Name: mitochondrial ribosomal protein L10 Category: mRNA Synonyms: L10MT|MRP-L10|MRP-L8|MRPL8|RPML8 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 47823272 End Site(bp): 47831534 Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010] External Links: Ensembl ID: ENSG00000159111 HGNC ID: HGNC:14055 Entrez Gene: 124995

Expression Profile of MRPL10 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-134-5p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-328-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO Display: