ctcRbase

Entry Detail

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General Information

Database ID: SKCM02751 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: EIF2AK2 Full Name: eukaryotic translation initiation factor 2 alpha kinase 2 Category: mRNA Synonyms: EIF2AK1|PKR|PPP1R83|PRKR Chromosome: chr2 Strand: - Coordinate: Start Site(bp): 37099210 End Site(bp): 37157065 Gene Summary: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] External Links: Ensembl ID: ENSG00000055332 HGNC ID: HGNC:9437 Entrez Gene: 5610

Expression Profile of EIF2AK2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-217 YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: