ctcRbase

Entry Detail

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General Information

Database ID: SKCM02774 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: BPTF Full Name: bromodomain PHD finger transcription factor Category: mRNA Synonyms: FAC1|FALZ|NEDDFL|NURF301 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 67825524 End Site(bp): 67984378 Gene Summary: This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000171634 HGNC ID: HGNC:3581 Entrez Gene: 2186

Expression Profile of BPTF Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-136-5p YES YES YES hsa-miR-139-5p YES YES NO hsa-miR-147a YES NO NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-149-5p YES YES YES hsa-miR-152-3p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-376a-3p YES YES YES hsa-miR-376b-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-424-5p YES NO YES hsa-miR-429 YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-433-3p YES YES YES hsa-miR-448 YES NO YES hsa-miR-454-3p YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES NO YES hsa-miR-503-5p YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-875-5p YES YES NO hsa-miR-876-5p YES YES YES Display: