ctcRbase

Entry Detail

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General Information

Database ID: SKCM02785 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: POT1 Full Name: protection of telomeres 1 Category: mRNA Synonyms: CMM10|GLM9|HPOT1 Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 124822386 End Site(bp): 124929983 Gene Summary: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000128513 HGNC ID: HGNC:17284 Entrez Gene: 25913

Expression Profile of POT1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-9-5p YES YES NO hsa-miR-96-5p YES YES NO Display: