ctcRbase

Entry Detail

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General Information

Database ID: SKCM02809 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: NPC1 Full Name: NPC intracellular cholesterol transporter 1 Category: mRNA Synonyms: NPC|POGZ|SLC65A1 Chromosome: chr18 Strand: - Coordinate: Start Site(bp): 23506184 End Site(bp): 23586898 Gene Summary: This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009] External Links: Ensembl ID: ENSG00000141458 HGNC ID: HGNC:7897 Entrez Gene: 4864

Expression Profile of NPC1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-137 YES YES YES hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES YES hsa-miR-485-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES YES NO hsa-miR-96-5p YES YES NO Display: