ctcRbase

Entry Detail

---



General Information

Database ID: SKCM02819 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: KANK1 Full Name: KN motif and ankyrin repeat domains 1 Category: mRNA Synonyms: ANKRD15|CPSQ2|KANK Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 470291 End Site(bp): 746106 Gene Summary: The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014] External Links: Ensembl ID: ENSG00000107104 HGNC ID: HGNC:19309 Entrez Gene: 23189

Expression Profile of KANK1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-134-5p YES YES NO hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-138-5p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-183-5p YES NO YES hsa-miR-195-5p YES YES YES hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-31-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES YES hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES YES NO hsa-miR-506-3p YES YES YES hsa-miR-542-3p YES YES NO hsa-miR-873-5p YES YES NO Display: