ctcRbase

Entry Detail

---



General Information

Database ID: SKCM02844 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: UACA Full Name: uveal autoantigen with coiled-coil domains and ankyrin repeats Category: mRNA Synonyms: NUCLING Chromosome: chr15 Strand: - Coordinate: Start Site(bp): 70654554 End Site(bp): 70763593 Gene Summary: This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017] External Links: Ensembl ID: ENSG00000137831 HGNC ID: HGNC:15947 Entrez Gene: 55075

Expression Profile of UACA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-137 YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-496 YES YES NO hsa-miR-519d-3p YES YES NO Display: