ctcRbase

Entry Detail

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General Information

Database ID: SKCM02902 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CDC27 Full Name: cell division cycle 27 Category: mRNA Synonyms: ANAPC3|APC3|CDC27Hs|D0S1430E|D17S978E|H-NUC|HNUC|NUC2 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 47117703 End Site(bp): 47189422 Gene Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014] External Links: Ensembl ID: ENSG00000004897 HGNC ID: HGNC:1728 Entrez Gene: 996

Expression Profile of CDC27 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p NO YES YES hsa-miR-107 NO YES YES hsa-miR-145-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-182-5p YES YES YES hsa-miR-195-5p YES NO YES hsa-miR-200b-3p NO YES YES hsa-miR-200c-3p NO YES YES hsa-miR-223-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-302a-3p NO YES YES hsa-miR-302b-3p NO YES YES hsa-miR-302c-3p NO YES YES hsa-miR-302d-3p NO YES YES hsa-miR-302e NO YES YES hsa-miR-32-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-372-3p NO YES YES hsa-miR-373-3p NO YES YES hsa-miR-424-5p YES YES YES hsa-miR-429 NO YES YES hsa-miR-433-3p YES YES NO hsa-miR-493-3p YES NO YES hsa-miR-497-5p YES NO YES hsa-miR-520a-3p NO YES YES hsa-miR-520b NO YES YES hsa-miR-520c-3p NO YES YES hsa-miR-520d-3p NO YES YES hsa-miR-520e NO YES YES hsa-miR-873-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: