ctcRbase

Entry Detail

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General Information

Database ID: SKCM02940 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ETV1 Full Name: ETS variant 1 Category: mRNA Synonyms: ER81 Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 13891228 End Site(bp): 13991425 Gene Summary: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016] External Links: Ensembl ID: ENSG00000006468 HGNC ID: HGNC:3490 Entrez Gene: 2115

Expression Profile of ETV1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-129-5p YES YES YES hsa-miR-132-3p YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-144-3p YES NO YES hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES NO YES hsa-miR-152-3p YES NO YES hsa-miR-155-5p YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-193a-3p YES YES YES hsa-miR-193b-3p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-212-3p YES YES YES hsa-miR-214-3p YES NO NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-365a-3p YES YES YES hsa-miR-409-3p YES NO YES hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-448 YES YES YES hsa-miR-455-3p YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-519d-3p YES YES YES hsa-miR-532-3p YES NO YES hsa-miR-582-5p YES NO YES hsa-miR-93-5p YES YES YES Display: