ctcRbase

Entry Detail

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General Information

Database ID: SKCM02968 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SPRY2 Full Name: sprouty RTK signaling antagonist 2 Category: mRNA Synonyms: IGAN3|hSPRY2 Chromosome: chr13 Strand: - Coordinate: Start Site(bp): 80335976 End Site(bp): 80340951 Gene Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000136158 HGNC ID: HGNC:11270 Entrez Gene: 10253

Expression Profile of SPRY2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO YES hsa-miR-107 YES NO YES hsa-miR-122-5p YES YES YES hsa-miR-124-3p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-136-5p YES YES NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-183-5p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-448 YES YES YES hsa-miR-506-3p YES YES YES hsa-miR-590-5p YES YES YES hsa-miR-599 YES YES NO hsa-miR-653-5p YES YES NO Display: