ctcRbase

Entry Detail

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General Information

Database ID: SKCM03063 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: NEDD4L Full Name: neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Category: mRNA Synonyms: NEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2 Chromosome: chr18 Strand: + Coordinate: Start Site(bp): 58044367 End Site(bp): 58401540 Gene Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] External Links: Ensembl ID: ENSG00000049759 HGNC ID: HGNC:7728 Entrez Gene: 23327

Expression Profile of NEDD4L Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-130a-3p YES NO YES hsa-miR-130b-3p YES NO YES hsa-miR-142-5p YES NO YES hsa-miR-15b-5p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-200b-3p YES NO YES hsa-miR-200c-3p YES NO YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-24-3p YES NO YES hsa-miR-25-3p YES NO YES hsa-miR-301a-3p YES NO YES hsa-miR-301b-3p YES NO YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-32-5p YES NO YES hsa-miR-339-5p YES NO YES hsa-miR-363-3p YES NO YES hsa-miR-367-3p YES NO YES hsa-miR-374a-5p NO YES YES hsa-miR-374b-5p NO YES YES hsa-miR-429 YES NO YES hsa-miR-433-3p YES YES NO hsa-miR-454-3p YES NO YES hsa-miR-519d-3p YES YES YES hsa-miR-875-5p YES NO YES hsa-miR-92a-3p YES NO YES hsa-miR-92b-3p YES NO YES hsa-miR-93-5p YES YES YES Display: