ctcRbase

Entry Detail

---



General Information

Database ID: SKCM03184 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: COASY Full Name: Coenzyme A synthase Category: mRNA Synonyms: DPCK|NBIA6|NBP|PPAT|UKR1|pOV-2 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 42561467 End Site(bp): 42566277 Gene Summary: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014] External Links: Ensembl ID: ENSG00000068120 HGNC ID: HGNC:29932 Entrez Gene: 80347

Expression Profile of COASY Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-326 YES YES NO hsa-miR-328-3p YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-543 YES YES NO Display: