ctcRbase

Entry Detail

---



General Information

Database ID: SKCM03201 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SENP6 Full Name: SUMO specific peptidase 6 Category: mRNA Synonyms: SSP1|SUSP1 Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 75601509 End Site(bp): 75718278 Gene Summary: Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009] External Links: Ensembl ID: ENSG00000112701 HGNC ID: HGNC:20944 Entrez Gene: 26054

Expression Profile of SENP6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-194-5p NO YES NO hsa-miR-196a-5p NO YES YES hsa-miR-196b-5p NO YES YES hsa-miR-217 YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-300 YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-496 YES YES NO hsa-miR-599 YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-876-5p NO YES YES Display: