ctcRbase

Entry Detail

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General Information

Database ID: SKCM03228 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: EP300 Full Name: E1A binding protein p300 Category: mRNA Synonyms: KAT3B|RSTS2|p300 Chromosome: chr22 Strand: + Coordinate: Start Site(bp): 41091786 End Site(bp): 41180079 Gene Summary: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000100393 HGNC ID: HGNC:3373 Entrez Gene: 2033

Expression Profile of EP300 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-1271-5p YES YES YES hsa-miR-129-5p YES YES YES hsa-miR-1297 YES YES YES hsa-miR-132-3p YES YES YES hsa-miR-138-5p YES YES NO hsa-miR-147a YES NO NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-150-5p YES YES YES hsa-miR-152-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-186-5p YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-212-3p YES YES YES hsa-miR-22-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-296-3p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-326 YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-342-3p YES YES YES hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES YES hsa-miR-431-5p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-96-5p YES YES YES Display: