ctcRbase

Entry Detail

---



General Information

Database ID: SKCM03231 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RB1 Full Name: RB transcriptional corepressor 1 Category: mRNA Synonyms: OSRC|PPP1R130|RB|p105-Rb|pRb|pp110 Chromosome: chr13 Strand: + Coordinate: Start Site(bp): 48303751 End Site(bp): 48481986 Gene Summary: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000139687 HGNC ID: HGNC:9884 Entrez Gene: 5925

Expression Profile of RB1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-132-3p YES YES YES hsa-miR-143-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-192-5p YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-3p YES NO YES hsa-miR-199b-5p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-212-3p YES YES YES hsa-miR-215-5p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-335-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-576-5p YES NO NO hsa-miR-7-5p YES YES YES hsa-miR-93-5p YES YES YES hsa-miR-98-5p YES NO YES Display: