ctcRbase

Entry Detail

---



General Information

Database ID: SKCM03254 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TWIST1 Full Name: twist family bHLH transcription factor 1 Category: mRNA Synonyms: ACS3|BPES2|BPES3|CRS|CRS1|CSO|SCS|SWCOS|TWIST|bHLHa38 Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 19020991 End Site(bp): 19117672 Gene Summary: This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000122691 HGNC ID: HGNC:12428 Entrez Gene: 7291

Expression Profile of TWIST1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1251-5p YES NO YES hsa-miR-1271-5p YES YES NO hsa-miR-127-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-151a-3p YES NO YES hsa-miR-182-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-326 YES NO YES hsa-miR-330-5p YES NO YES hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-361-5p YES YES YES hsa-miR-409-3p YES NO YES hsa-miR-532-5p YES NO YES hsa-miR-543 YES YES YES hsa-miR-876-5p YES YES NO hsa-miR-9-5p YES YES NO hsa-miR-96-5p YES YES NO Display: