ctcRbase

Entry Detail

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General Information

Database ID: SKCM03315 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SMAD4 Full Name: SMAD family member 4 Category: mRNA Synonyms: DPC4|JIP|MADH4|MYHRS Chromosome: chr18 Strand: + Coordinate: Start Site(bp): 51028394 End Site(bp): 51085045 Gene Summary: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000141646 HGNC ID: HGNC:6770 Entrez Gene: 4089

Expression Profile of SMAD4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES NO hsa-miR-1-3p NO YES YES hsa-miR-146a-5p YES YES YES hsa-miR-146b-5p YES YES YES hsa-miR-183-5p YES NO YES hsa-miR-206 NO YES YES hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-34a-5p NO YES YES hsa-miR-34c-5p NO YES YES hsa-miR-376c-3p YES YES NO hsa-miR-431-5p YES NO YES hsa-miR-449a NO YES YES hsa-miR-449b-5p NO YES YES hsa-miR-495-3p YES YES NO hsa-miR-599 YES YES NO hsa-miR-613 YES YES NO Display: